Oral hypoglycaemic activity of Binkohomba (Munronia pinnata) on type 2 diabetic subjects

INTERVENTION: The study will be conducted at the OPD clinic of the Dravyaguna Vignana Department of the National Hospital of Ayurveda, Borella. Consenting participants meeting inclusion/exclusion criteria will be randomized into three groups (n=30 in each) using computer generated random numbers. Group 1 will receive the aqueous extract of the calli of M. pinnata (60g/kg, 120ml twice a day) for 3 months, in addition to diet control. Group 11 will be receive the aqueous extract of the natural plants of M. pinnata (60g/kg, 120mL per twice a day) for three months in addition to diet control(recommended dose in Ayurveda (Sharma,1996 ). Group 111 will be on diet control only. All patients will receive detailed advice on diet as indicated in the national guidelines for the management of Type II diabetics (SLMA, 2000) Total duration of the intervention is three months CONDITION: Type 2 diabetes mellitus PRIMARY OUTCOME: 1. Fasting blood glucose; 2. Oral glucose tolerance test (OGTT); 3. HbA1c; SECONDARY OUTCOME: Changes in liver enzymes (AST and ALT) and serum creatinine INCLUSION CRITERIA: 1. Type II diabetic patients only on diet control. 2. Ability to read and understand Sinhala or English 3. Patients who present to the OPD clinic of the Dravyaguna Vignana Department at the National Hospital of Ayurveda, Borella