A randomized, double-blind, placebo-controlled trial to assess the safety, pharmacokinetics, and efficacy of escalating doses of oral ivermectin in scabies infected children weighing 5 to less than 15 kilograms

INTERVENTION: Ivermectin 3mg tablets Permethrin cream CONDITION: ; skin infestation ,Scabies skin infestation ,Scabies PRIMARY OUTCOME: Pruritus is the primary adverse event of concern that will be assessed from all treatment arms. SECONDARY OUTCOME: Ivermectin and metabolite concentrations (e.g. Cmax, Tmax, area‐under‐the‐curve). Reduction in scabies burden INCLUSION CRITERIA: • Male or female child weighing 5 to <15 kilograms • =2 months old • Scabies infestation • Available to attend all study visits • Parents/guardians/carers able to provide consent