A Comparative Single Blind Clinical Study on the Effect of Alvogyl, Eugenol, and Nigella Sativa (Black Seed Oil) for Alveolar Osteitis.

Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
Dry socket the unscientific term also known as alveolar or fibrinolytic osteitis is themost common postoperative complication following tooth extraction. Dry socket lesionoccur in approximately 1% to 5% of all extraction and up to 38% of mandibular third molarextractions. The etiology of dry socket is not yet fully understood, however thedisintegration of the blood clot at the site of the tooth extraction fails to developi.e. fibrinolysis is widely accepted as the primary mechanism or it dislodges beforewound has healed. Various factors have been associated with an increase of dry socket,although some of them remain controversial and many include difficult or traumaticextractions, oral hygiene, smoking, Gender (female), extraction site, previous dry sockethistory, while incidence can be reduced with the chlorhexidine rinse and gel of alveolarosteitis.Treatment of Alveolar osteitis can be either pharmacological on non‐pharmacological.Management can be by irrigation, surgical intervention and placement of medicateddressing such as topical anti‐bacterial, topical anesthetics and obtundants orcombination of these three. Out of these Alveogyl is the still the material of choice interms of pain relief, wound healing and low incidence of dry socket as compared to honey,zinc oxide eugenol and cutanplast , however in some recent studies a mixture of Nigellasativa powder and oil showed that it is more efficacious dressing material for themanagement of dry socket compared to alvogyl, it provided immediate and complete painrelief and fewer number of repeated visits needed while in some neocane was the mostsuitable dressing material for the management of dry socket by virtue of shorter timerequired for the complete pain relief, fewer visits required and faster clinical healing.Based on the previous data, we decided to conduct a study to evaluate the effectivenessof nigella sativa (black seed oil) for the treatment of dry socket compared to alveogyland eugenol both. To the best of our knowledge, this is the first comparative study ofnigella sativa oil for the treatment of dry socket at Oral and maxillofacial surgerydepartment, HITEC dental college, Taxila and is aimed to find the best and effectivetreatment for dry socket comparing Alveogyl, Eugenol and Black seed oil at thisinstitution.
Epistemonikos ID: a9c5aa0d230c3a2f0df1a26d23390f1472298104
First added on: Mar 27, 2025