Innovative Interstitial Injection Therapy as an Alternative to Surgery for Inhibiting Port-Wine Stain-Associated Facial and Labial Hypertrophy and Asymmetrical Deformity: a Single-Center, Randomized Controlled Trial

INTERVENTION: Pingyangmycin Injection Group:Intralesional interstitial injection of Pingyangmycin;Control Group:An equal volume of placebo mixture; CONDITION: Port wine stain, PWS PRIMARY OUTCOME: Degree of reduction in hypertrophic lesion volume; SECONDARY OUTCOME: Micro‐ultrasound detection of lesion thickness and blood flow;3D scanning to evaluate surface volume;Visual Analog Scale (VAS) scoring method;Objective detection of lesion color using a photometer; INCLUSION CRITERIA: 1. Patients with facial and lip enlargements and asymmetrical deformities associated with port‐wine stains who meet the diagnostic criteria for vascular malformations in the guidelines for hemangioma and vascular malformation treatment, and have been confirmed by at least three clinicians. 2. Aged 8‐50 years (including 8 and 50), any gender; 3. Have not received any other injection treatments in the past 3 months;