The effects of lacosamide and toptramate combination therapy on chronic migraine

INTERVENTION: Intervention 1: Intervention group: In the first week, all patients will receive lacosamide 100 mg twice a day, and from the second week, they will also receive 150 mg every 12 hours, and in the third week, 200 mg twice a day, if they tolerate, and they will also receive topiramate 25 mg once a day in the first week and after that 25 mg twice a day. Intervention 2: Control group: all patients will receive placebo with the same shape and color as lacosamide twice a day, and they will also receive topiramate 25 mg once a day in the first week and after that 25 mg twice a day. CONDITION: Migraine Headache. ; Migraine PRIMARY OUTCOME: The number of days that the individual has experienced headache. Timepoint: At the beginning of the study, in the 8th week (56 days after baseline) and in the 11th week (84 days after baseline). Method of measurement: History taking. The number of headache attacks. Timepoint: weekly, up to 12 weeks. Method of measurement: Visual analogue scale (VAS). SECONDARY OUTCOME: Disability improvement. Timepoint: Baseline and third month. Method of measurement: Migraine Disability Assessment. INCLUSION CRITERIA: Adults over 18 years old migraine (with or without aura) moderate to high intensity migraine headache (VAS=4)