Prediction of portal vein thrombosis after splenectomy and its primary prophylaxis with antithrombin III concentrates in liver cirrhosis with portal hypertension

INTERVENTION: intravenous infusion of 1,500 units of AT‐III concentrates (Anthrobin P®; CSL Behring, Tokyo, Japan) over approximately 1 hour on postoperative day 1, 2, and 3 intravenous administration of AT‐III concentrates (1500 units/day) for three days followed by intravenous administration of danaparoid Na (2,500 units/day) for 7 14 days and subsequent administration of warfarin No treatment CONDITION: Cirrhotic patients who underwent laparoscopic splenectomy PRIMARY OUTCOME: To classify risk level of portal vein thrombosis (PVT) after splenectomy in cirrhotic patients SECONDARY OUTCOME: To develop prophylactic treatments of PVT according to the risk level of PVT after splenectomy in cirrhotic patients INCLUSION CRITERIA: Cirrhotic patients who underwent laparoscopic splenectomy