Effectiveness of Single Dose Intravenous Aminophylline Administration on Prevention of Post Dural Puncture Headache in Patients Who Received Spinal Anesthesia for Elective Cesarean Section

Post dural puncture headache is a relatively common complication in spinal anesthesia, so several kinds of regimens has been suggested for treatment of this problem. The aim was to determine whether single dose of intravenous aminophylline (1-1.5-mg/kg) can decrease the incidence of this complication in cesarean section or not. So in a double blind randomized study, 120 patients undergoing spinal anesthesia for the elective cesarean section, participated. After cord clamping, 1mg/ kg aminophylline injected intravenously in 60 patient but others didnt receive it. At 1 , 4 , 24 and 48 hours after operation, these 120 patients evaluated ' st th th th for Post dural puncture headache. Data was analyzed statistically by independent T-test and chi-square between two groups. Results showed that the incidence rate of post dural puncture headache is significantly lower than control one (5% vs 23.3%, P<0.001) and severe headache after 48 hours was 3 and 11% respectively. It seems that the incidence of post dural puncture headache decreases in those patients who received single dose intravenous aminophylline after cord clamping. The article can potentially help clinicians to use different combinations of effective drugs for preventing pains instead of curing them.