Comparative Analysis of Oral Iron With Injectable Ferric Carboxymaltose for Post Partum Iron Deficiency Anaemia

The aim of this open label, interventional, randomized controlled clinical trial is tocompare the efficacy and safety of ferric carboxymaltose injection with oral iron intreatment of postpartum iron deficiency anaemia in postnatal women. Inclusioncriteria:women within 10 days of delivery, Hb >7 gm/dl and ≤10 gm and peripheral smearshowing microcytic hypochromic anaemia or red cell indices suggestive of iron deficiencyanaemia or Mentzer index >13.Primary outcome measures‐rise in Hb from baseline to 4 and 6 weeks Secondary outcomemeasures‐Percentage of patients achieving Hb >11 g/dl at 4 and 6 weeks.Percentage of patients achieving Hb rise >3 g/dl from baseline at 4 and 6 weeks Change inred cell indices and peripheral smear from baseline to 6 weeks Side effects profile ofinjectable Ferric carboxymaltose injection and oral iron.Researcher compares the efficacy and safety of ferric carboxymaltose with Oral iron inpost partum iron deficiency anaemia Participant's detailed history, general physical andsystemic examination was performed. CBC with red cell indices, reticulocyte counts,peripheral smear examination, serum Iron, Ferritin, Transferrin, TIBC levels and LFT weredone.Subjects were randomized in a 1:1 ratio into two groups: Group I (n=100) receivedintravenous ferric carboxymaltose and Group II (n=100) received oral ferrous Fumaratetwice a day for 6 weeks.All subjects were followed at 4 and 6 weeks. Repeat Hb estimation was done at 4 and 6weeks while RBC indices and serum iron parameters were repeated at 6 weeks. Adverseeffects were recorded.