The POPS trial (PICC Out Parenteral nutrition Stopped): In preterm infants less than 1500grams, does stopping intravenous nutrition and removing Peripherally Inserted Central Venous Catheters (PICC lines) at 100mls/kg/day of oral feeds compared to 140mls/kg/day (full oral feeds) significantly increase time to regain birth-weight?

Authors
Category Primary study
Registry of TrialsISRCTN registry
Year 2013
INTERVENTION: Removal of PICC line at 100mls/kg/day of enteral feeds compared to 140mls/kg/day (full feeds). Participants will be followed until their discharge from hospital. CONDITION: Very Low Birth Weight / extremely premature infants: Nutrition and Late onset sepsis (LOS), CVC/PICC complications ; Pregnancy and Childbirth ; Extremely low birth weight PRIMARY OUTCOME: To compare the two allocation groups with respect to the time taken to regain birth weight. This will be calculated in days from birth. Infants are weighed daily. SECONDARY OUTCOME: To compare the two allocation groups with respect to the following:; 1. Episodes of CVC associated blood stream infection/Late onset infection (>72hours); 2. PICC complications (thrombosis, infiltration, leaking, thrombophlebitis, superficial skin infection at site); 3. Hypoglycaemia ? Point Of Care Testing (POCT) glucose =2.6mmol/L within 24 hours of PICC line removal; 4. Peripheral IV inserted within 24hours of PICC removal for the purpose of IV hydration; 5. Discharge weight (kg), occipital‐frontal circumference (OFC) (cm) and length (cm) and centiles (WHO centile chart); 6. The mean difference in calorie, carbohydrate, lipid and protein intake between between removal of PICC line and 140mls/kg/day; 7. Mean duration PICC line in situ, calculated in hours INCLUSION CRITERIA: 1. Very Low Birth Weight Infants (less than 1500g) who are initiating enteral feeding 2. Peripherally inserted central catheter (PICC) in situ
Epistemonikos ID: a627df04019faaf37a137bba0be594f2d9336efb
First added on: Aug 22, 2024