A randomized, double-blind, placebo-controlled trial of acetazolamide for the treatment of elevated intracranial pressure in cryptococcal meningitis

Authors
Category Primary study
JournalCLINICAL INFECTIOUS DISEASES
Year 2002
We conducted a trial of oral acetazolamide for the treatment of cryptococcal meningitis in 22 Thai adults with headache and an opening cerebrospinal fluid pressure of greater than or equal to200 mm H(2)0. The trial was terminated prematurely because patients who received acetazolamide developed significantly lower venous bicarbonate levels and higher chloride levels and had more-frequent serious adverse events than did subjects who received placebo.
Epistemonikos ID: a550cdfe4ea49e368c87805e2aa2d0834b776ee7
First added on: Jun 08, 2011