Influence of drug containing ginger extract on arthritic pain and gastropathy in patients with osteoarthritis

INTERVENTION: The patients were randomised in two groups, using methods of envelopes, to: 1. Group ZG (n = 21): ginger and glucosamine combination (Zinaxin Glucosamine: 170 mg ginger extract [Zingiber officinalis, EV.EXT 35] and 500 mg glucosamine, as glucosamine sulphate, per capsule, Ferrosan AS, Denmark) 2 capsules orally daily 2. Group DG (n = 22): diclofenac and glucosamine combination (100 mg diclofenac as sodium diclofenac and 1000 mg glucosamine as glucosamine sulphate) daily The duration of treatment was 28 days. CONDITION: Osteoarthritis, NSAID‐induced gastropathy ; Musculoskeletal Diseases ; Osteoarthritis PRIMARY OUTCOME: Upper GI lesions (erosion, ulcer) were assessed on the 28 day of treatment with upper GI endoscopy SECONDARY OUTCOME: Gastritis INCLUSION CRITERIA: 1. Aged over 18 years, either sex 2. Osteoarthritis (OA) pain syndrome availability of more than 40 mm according to Visual Analogue Scale (VAS) 3. Requiring anti‐inflammatory therapy assignment 4. NSAID‐gastropathy or dyspepsia development from NSAID therapy in anamnesis 5. Informed patient consent to administer the preparation 6. Compliance with the listed research protocol