Cellular effects and clinical effectiveness of currently prescribed doses of carbamide peroxide tooth whitening products

INTERVENTION: 1. Treatment with whitening kits with 10% carbamide peroxide 2. Treatment with whitening kits with 16% carbamide peroxide 3. Treatment with whitening kits with 22% carbamide peroxide 4. Treatment with inactive gel 5. Treatment with 16% whitening strips carbamide peroxide Total duration of active tooth whitening treatment was 14 days. Patient were seen for clinical assessement on Day 0 (start), Day 14 and at 3 months for final review. CONDITION: Tooth whitening ; Oral Health ; Tooth whitening PRIMARY OUTCOME: Current information as of 26/01/2009:; Alteration in tooth colour from the three prescribed agents (non‐active placebo, 10% carbamide peroxide and 16% carbamide peroxide) during a 2 week course of tooth whitening and the overall colour stability at 3 months. ; ; Initial information at time of registration:; 1. To measure the efficacy of carbamide peroxide concentration on rate and longevity of tooth shade variation; 2. To investigate the effect of currently used dosages of carbamide peroxide on human oral epithelium SECONDARY OUTCOME: Added 26/01/2009:; 1. Soft tissue changes during the active treatment period and on subsequent review; 2. Tooth senstivitiy over the active treatment period; 3. Patients perceptions of tooth colour at baseline, 2 weeks and 3 months INCLUSION CRITERIA: Healthy volunteers (aged 19‐ 53 years, either sex)