GOC2: Amulticenter prospective trial comparing open, laparoscopic and robotic surgical outcomes in women with endometrial cancer. Part B: Patient-reported outcomes

Objective: GOC2 is a multicenter prospective cohort study comparing minimally invasive surgery (MIS, laparoscopy [LPS] and robotic) to open surgery in the primary treatment of women with endometrial cancer (EC). The objective was to evaluate perioperative, patientreported, and cost-effectiveness outcomes between these groups. This abstract presents the PROs data including quality of life (QOL), pain, and sexual health. Method: Between 2012 and 2014women from8 centers were enrolled. Overall QOL and pain were measured using the Functional Assessment of Cancer Therapy-Endometrial (FACT-EN) and Brief Pain Inventory (BPI) at baseline and 1 week, 3 weeks, and 3/6 months after surgery. Sexual healthwasmeasured using the Female Sexual Functioning Index (FSFI) and the Sexual Adjustment and Body Image Scale-Gynecology (SABIS-G) at baseline and 3/6 months after surgery. Primary analysis was between MIS and open surgery using t test or Wilcoxon test as appropriate. Results: A total of 389 women were included in the analysis: 86 open and 303 MIS (137 LPS, 166 robotic). Therewas no difference in baseline scores of the FACT-EN or BPI between MIS versus open surgery or between LPS or robotic groups (P N 0.5).Womenwho had open surgery had significantly lower FACT-EN scores (worse QOL) and higher BPI (higher pain) scores compared to the MIS group at weeks 1 and 3 postsurgery (P < 0.001). At 3 and 6 months the BPI scores had reached baseline andwere not different between groups (P N 0.5). The FACT-EN scores were lower in the open surgery group at 3 and 6 months (P < 0.04). Women undergoing open surgery had lower FSFI (worse sexual functioning) and SABIS-G (worse sexual distress) compared to the MIS group at baseline (P < .02). The FSFI scores increased in both surgical groups; however, it remained significantly lower in the open compared to the MIS group at 3 and 6 months (P < 0.04). The SABIS-G scores remained stable at 3 and 6 months for the MIS group; however, they were significantly greater than those for the open surgery group at 3 months (P = 0.028) and similar at 6 months (P= 0.17). Conclusion: This study confirms the benefit of MIS (robotic or LPS) surgery for women with EC with improved QOL and pain in the first 3 weeks postoperatively. Even though QOL and pain are equivalent at baseline, sexual health status at baseline is worse for women who undergo open surgery compared toMIS and improves minimallywithin first 6 months.