Comparison of Office and Cuffless Ambulatory Blood Pressure-Guided Management in Patients With Hypertension

Hypertension is a major risk factor for cardiovascular and cerebrovascular diseases,including stroke and myocardial infarction. Blood pressure (BP) fluctuates throughout theday in response to physical activity, emotional states, and sleep. However, hypertensiondiagnosis and management are commonly based on BP measurements obtained in the clinic orat home, which may not fully reflect these variations. This can contribute todiscrepancies between office and out‐of‐office BP, including white‐coat and maskedhypertension.Ambulatory blood pressure monitoring (ABPM) provides information on BP throughout dailyactivities and sleep, but conventional cuff‐based ABPM may be limited by discomfort,accessibility, and logistical challenges. Recently, cuffless wearable devices haveenabled repeated BP monitoring without the use of a conventional inflatable cuff.The CUFFLESS study is a multicenter, prospective, randomized controlled trial comparingtwo strategies for the management of hypertension: cuffless ambulatory BP‐guidedmanagement and conventional office BP‐guided management. Participants will be randomlyassigned to either management strategy and followed for clinical outcomes. The primaryobjective is to determine whether hypertension management guided by cuffless ambulatoryBP monitoring reduces the occurrence of cardiovascular events compared with managementguided by conventional office BP measurements.