Adipocytokine regulation by antihypertensive drugs in patients with essential hypertension

INTERVENTION: The hypertensive patients under amlodipine administration are intended for enrolement of this study. The patients are assigned to Group A (amlodipine). The hypertensive patients under amlodipine administration are intended for enrolement of this study. The patients are assigned to Group B (Olmesartan or Telmisartan). As to Group B, the patiens are assigned to Olmesartan or Telmisartan at random. CONDITION: Hypertension PRIMARY OUTCOME: The plasma levels of adipocytokines (Adiponectin, Omentin, Aedipolin, C1q/TNF‐related protein (CTRP)‐1,6,9, FAM132B, FSTL‐1, C1ORF54, Neuron‐derived neurotrophic factor (NDNF)) after 4 months. SECONDARY OUTCOME: Blood pressure; Clinical data INCLUSION CRITERIA: The hypertensive patients under amlodipine administration for more than 3 months are intended for enrolement of this study. 1. Age; over 20 years old 2. Clinical data AST<100IU/L ALT<100IU/L Cre<1.5mg/dl 3. Informed consent is needed.