Dose-response to coenzyme Q10 supplementation with Q-Gel

Category Primary study
Registry of TrialsANZCTR
Year 2005
INTERVENTION: Four different treatments are to be used in this study. 1)single oral dose of 60 mg of coenzyme Q10 supplement Q‐Gel (2 x 30 mg capsules); 2) single oral dose of 150 mg of coenzyme Q10 supplement Q‐Gel (5 x 30 mg capsules); 3) single oral dose of 300 mg of coenzyme Q10 supplement Q‐Gel (10 x 30 mg capsules); 4) single oral dose of 300 mg of coenzyme Q10 supplement Q‐Gel (3 x 100 mg capsules). Each participant will receive all four treatments, one per week for four weeks. Treatments will be given between 0800 and 0900 hours, after an overnight fast. For all doses, blood samples will be drawn at time 0, 2, 4, 6, 8, and 10 hours after the dose for the measurement of coenzyme Q10 in plasma. Lipid profiles (total cholesterol, LDL‐ and HDL‐cholesterol and triglycerides) will also be measured on all samples. CONDITION: Healthy Volunteers None PRIMARY OUTCOME: The increase in plasma CoQ10 after supplementation with varying doses of the CoQ10 supplement Q‐Gel, for a period of 10 hours after ingestion of the supplement SECONDARY OUTCOME: The increase in plasma CoQ10 after supplementation given as 3 x 300 mg supplements and 10 x 30 mg, for a period of 10 hours after ingestion of the supplements, will be compared. INCLUSION CRITERIA: Healthy.
Epistemonikos ID: a1208d66b9ba9d205a615b1e5071f082288504b0
First added on: Aug 25, 2024