Loratadine effect on the rate of rehospitalization and recurrent angina in patients with acute coronary syndrome

INTERVENTION: Control group: Aspirint oral tablet 80 mg daily + Metoralt oral tablet 25‐50 mg towice in day Intervention 1: Intervention group: Loratadine, oral tablet, 10 mg daily for a one month course + Aspirin, oral tablet 80 mg daily + Metoral, oral tablet 25‐50 mg towise in day. Intervention 2: Control group: Aspirint oral tablet 80 mg daily + Metoralt oral tablet 25‐50 mg towice in day. Intervention group: Loratadine, oral tablet, 10 mg daily for a one month course + Aspirin, oral tablet 80 mg daily + Metoral, oral tablet 25‐50 mg towise in day Treatment ‐ Drugs CONDITION: acute coronary syndrome. ; Acute ischaemic heart disease, unspecified Acute ischaemic heart disease, unspecified PRIMARY OUTCOME: Readmission. Timepoint: Baseline, the first, second , third, and fourth week after the intervention. Method of measurement: Visual analog scale of readmission. Recurrent angina. Timepoint: Baseline, the first, second , third, and fourth week after the intervention. Method of measurement: Descriptive scale of chest pain. SECONDARY OUTCOME: Side effects of loratadine. Timepoint: Baseline, the first, second , third, and fourth week after the intervention. Method of measurement: Descriptive scale of symptoms such as headache, insomnia, weakness. INCLUSION CRITERIA: INCLUSION CRITERIA: class 2 and 3 of Braunwald criteria Exclusion criteria: prior history of hospitalization due to acute coronary syndrome, presence of liver disease, using antihistamines drugs such drugs as Cimetidine, Erythromycin, Clarithromycin, anti‐fungal group and Fluoxetine