HIVIS03

INTERVENTION: Priming with intradermal DNA, Boosting with intradermal MVA Priming with intramuscular DNA, Boosting with intramuscular MVA Saline CONDITION: ; HIV/AIDS HIV/AIDS PRIMARY OUTCOME: Immunogenicity, cellular & Humoral Safety of Immunization INCLUSION CRITERIA: 18‐40 years Willing to be counseled & HIV tested Negative HIV Ag/Ab ELISA Informed consent Minimum 7 years of 1° Education. Resident in Dar es Salaam At low risk of HIV, (absence of: sexual partner with HIV, partner with unknown HIV serostatus and unwilling to use protection in sexual relations, partner known to be at high risk for HIV, >1 sexual partner in last 6 months, alcoholic (>35 units/week), STI in past 6 months). Assurances for birth control measures till 4 months after last vaccination Negative UPT Willingness for safe sex practice Good health by clinical & lab parameters: (FBG <7.8 mmol/l, Hb >10.5g/dl, WBC count >1,300/mm3, Granulocytes >6.4/ mm3, Lymphocytes >1.0/ mm3, Platelets >120,000/ mm3, CD4 >400cells/mm3, RBG 2.5‐7.0 mmol/L; if elevated, then a FBG <7.8 mmol/l, Bilirubin <1.25 x uln, ALT <1.25 x uln, Creatinine <1.25 x uln, ‐ve/trace urine dipstick for protein and blood)