The antioxidant effects of Q10 co enzyme on oxidative stress and lipid per oxidation among gastric patients infected by h.pylori

Authors
Category Primary study
Registry of TrialsIranian Registry of Clinical Trials
Year 2014
INTERVENTION: Control group: Using three drugs regimen (bismuth sub citrate (120mg/kg QD), tetracycline (500mg QD) and metronidazole (400 mg/kg TD)) + placebo (lactolose) for 6 weeks. The types and dosages of drugs are not changed during treatment period. Intervention 1: Intervention group: Using three drugs regimen (bismuth sub citrate (120mg/kg QD), tetracycline (500mg QD) and metronidazole (400 mg/kg TD)) + Q10 coenzyme (2 mg/kg/day) for 6 weeks. The types and dosages of drugs are not changed during treatment period. Intervention 2: Control group: Using three drugs regimen (bismuth sub citrate (120mg/kg QD), tetracycline (500mg QD) and metronidazole (400 mg/kg TD)) + placebo (lactolose) for 6 weeks. The types and dosages of drugs are not changed during treatment period. Intervention group: Using three drugs regimen (bismuth sub citrate (120mg/kg QD), tetracycline (500mg QD) and metronidazole (400 mg/kg TD)) + Q10 coenzyme (2 mg/kg/day) for 6 weeks. The types and dosages of drugs are not changed during treatment period. Treatment ‐ Drugs CONDITION: Chronic gastritis, unspecified Gastritis. ; Chronic gastritis, unspecified k 29.5 PRIMARY OUTCOME: Glutation peroxidise. Timepoint: Start and end of study. Method of measurement: Serum level of studied marker by standard kits. Malondialdehyde. Timepoint: Start and end of study. Method of measurement: Serum level of studied marker by standard kits. Total antioxidant capacity (TAC). Timepoint: Start and end of study. Method of measurement: Serum level of studied marker by standard kits. INCLUSION CRITERIA: Including criteria: h. pylori infected gastric patients Excluding criteria: pregnancy; lactation; recent antibiotic application (6 recent weeks); recent attempt for h. pylori treatment; recent surgery of stomach; positive history of alcohol consumption or addiction; having infections or malignancies in other organs; cardiovascular diseases; diabetes; IBD .
Epistemonikos ID: 9fc3d3fcdab409f5ae71cc9ed7f6d7e678311692
First added on: Mar 23, 2022