Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne Vulgaris

This is a randomized, comparative clinical study designed to evaluate and compare thetherapeutic efficacy and safety profile of two different dosing regimens of oralisotretinoin in patients diagnosed with acne vulgaris.Eligible participants will be allocated into one of two treatment arms: 1. Experimental Arm (Low Dose): Participants will receive a low daily dose of oralisotretinoin. 2. Active Comparator Arm (Conventional Dose): Participants will receive the standardconventional daily dose of oral isotretinoin based on standard weight‐basedguidelines.Primary Outcome:Efficacy: Assessed by the percentage reduction in inflammatory and non‐inflammatory acnelesions from baseline, as well as The Global Acne grading System(GAGS) Safety andTolerability: Evaluated through the frequency, type, and severity of clinical adverseeffects (e.g., cheilitis, xerosis) and periodic laboratory monitoring (including lipidprofiles and liver function tests).Follow‐up visits will be conducted at regular intervals to monitor clinical response,manage side effects, and ensure patient compliance.