Clinical trial to evaluate efficacy and safety of low molecular collagen peptides for joint pain

INTERVENTION: Dietary Supplement : This trial is designed as a randomized, double‐blind, placebo‐controlled trial. The allocation ratio for each group is set as test group: control group = 1:1. *Daily intake and intake method ‐ Test food: 2 times a day, 4 tablets at a time, taken orally (as low molecular weight collagen peptide 4000 mg/day) ‐ Control food (placebo): Ingested in the same way as the test food * Intake period: 12 weeks CONDITION: Diseases of the musculoskeletal system and connective tissue PRIMARY OUTCOME: Change in Western Ontario and McMaster Universities (WOMAC) pain score after 12 weeks from baseline SECONDARY OUTCOME: Change in WOMAC pain score after 6 weeks from baseline Changes in VAS (Visual Analogue Scale) after 6 weeks and 12 weeks from baseline INCLUSION CRITERIA: (1) Adult men and women aged 40 years or older and less than 75 years old for more than 6 months after being diagnosed with knee arthritis (2) Those whose Kellgren‐Lawrence grading scale of one or both knee joints is grade I or II in simple radiographic examination (3) Those who have knee arthritis pain score of 30 mm or more evaluated by the Visual analog scale (VAS‐100 mm) (4) Those with a body mass inde X(BMI) of less than 30 kg/m2