The Effect of Hyaluronic Acid Injection on TNF-Alpha and IL-1ß in Knee Osteoarthritis

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
In this study, the effect of intra-articular HA injection therapy on pre- and post-treatment TNF-alpha and IL-1beta levels and methylation changes in blood and synovial fluid in patients with knee osteoarthritis will be determined and compared with the placebo group. In addition, the effects of HA injection on pain, functional status and quality of life will be evaluated and these effects will be related to changes in TNF-alpha and IL-1-beta.
Epistemonikos ID: 9de4bd015b23e040c31727bd71817194f802ab4d
First added on: May 08, 2025