Mindfulness-based intervention for very preterm young adolescents: An RCT

ObjectivesThis randomised controlled trial (RCT) assesses the effectiveness of a Mindfulness-Based Intervention (MBI) in improving executive, behavioural and socio-emotional competences in very preterm young adolescents. Methods58 young adolescents aged 10 to 14 years, born before 32 gestational weeks at the Geneva University Hospital, Switzerland, participated in the study. They were randomly assigned to an "intervention" or a "waiting" group and all completed an 8-week MBI in a cross-over design. Executive, behavioural and socio-emotional competences were assessed at three different time points via parent and self-reported questionnaires, neuropsychological testing, and computerised tasks. We analysed data using an intention-to-treat approach with linear modelling. Subgroups of participants based on levels of prematurity were created using k-means clustering. ResultsParent questionnaires revealed a statistically significant immediate effect of MBI with increased executive and behavioural competencies in everyday life. Increased executive competence was also observed on a Flanker task with enhanced speed of processing after MBI. Two subgroups of participants were created based on measures of prematurity, which revealed increased long-term benefits in the moderate-risk that are not observed in the high-risk subgroups of VPT young adolescents. ConclusionsOur findings show a beneficial effect of MBI on executive, behavioural and socio-emotional competences in VPT young adolescents. Moderate-risk and high-risk VPT young adolescents showed different immediate and long-term beneficial effects of the intervention. Our results suggest that MBI is a valuable tool for reducing detrimental consequences of prematurity in young adolescents, especially regarding executive, behavioural and socio-emotional difficulties. Data Sharing StatementDeidentified individual participant data (including data dictionaries) will be made available, in addition to study protocols, the statistical analysis plan, and the informed consent form. The data will be made available upon publication to researchers who provide a methodologically sound proposal for use in achieving the goals of the approved proposal. Proposals should be submitted to Russia.HaVinhLeuchter@unige.ch.