Therapeutic effect and safety of Huangkui Capsule for chronic kidney disease: a multi-center, randomized, open label study

INTERVENTION: A:Huangkui Capsule, 2.5g, tid,for 24 weeks;B:Losartan, 50mg qd, for 24 weeks;C:Huangkui Capsule, 2.5g, tid+ losartan 50mg qd, for 24 weeks; CONDITION: chronic kidney disease PRIMARY OUTCOME: 24 hour urinary protein excretion; SECONDARY OUTCOME: Level of serum cretinine, eGFR, serum albumin, CRP; INCLUSION CRITERIA: 1.Renal biopsy proven primary glomeruli disease in 1 year; 2. Age range 18‐70 years, male and female; 3. BP<=130/80mmHg(with or without drug); 4. eGFR>=60ml/min; 5. Proteinuria levels of 0.5 to 2.0g/24hr; 6. Signed the informed consent form.