Using vitamin K to improve strength and balance in older people

Authors
Category Primary study
Registry of TrialsISRCTN registry
Year 2015
INTERVENTION: Participants are randomly allocated into one of three groups: Group 1: Receive a daily oral dosing of 400mcg vitamin K2 (MK7 subtype) for a period of 12 months Group 2: Receive a daily oral 200mcg vitamin K2 (MK7 subtype) for a period of 12 months Group 3: Receive a daily oral dose of a placebo for a period of 12 months CONDITION: 1. Falls 2. Poor balance ; Signs and Symptoms ; 1. Falls 2. Poor balance PRIMARY OUTCOME: Difference in anterior‐posterior sway measured using a balance platform at baseline and 12 months. SECONDARY OUTCOME: 1. Additional markers of postural sway (mediolateral sway, 95% ellipse, RMS, total path length) measured using the AMTI sway meter at baseline, 6 and 12 months; 2. Berg balance scale compared between groups at baseline, 6 and 12 months; 3. Postural blood pressure drop on standing measured at baseline, 1 and 3 minutes after standing at 6 and 12 months; 4. Vitamin K levels are determined by measuring dp‐ucMGP levels in the blood at baseline and 12 months; 5. Physical function determined with a short physical performance battery, timed up and go test at each time point at baseline, 6 and 12 months; 6. Falls frequency determined from monthly falls diary to prospectively record falls; 7. Health and social care utilisation data collected using a healthcare data and patient questionnaire at baseline, 6 and 12 months INCLUSION CRITERIA: 1. Aged 65 years or over 2. Two or more self‐reported falls in the previous 12 months OR at least one fall resulting in hospitalisation in the previous 12 months 3. Able (in the Investigators opinion) and willing to comply with all study requirements.
Epistemonikos ID: 9c40ef44de026c1cc8f4032a82b1717a5d631302
First added on: Aug 23, 2024