Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety.

Category Primary study
JournalBioorganic & medicinal chemistry letters
Year 2000
In a program directed towards the design and synthesis of mimics of ganglioside GM1, the NeuAc recognition domain was replaced by simple hydroxy acids, and the affinity of the new ligands to the cholera toxin was determined by fluorescence spectroscopy. The (R)-lactic acid derivative 4 was found to display the highest affinity of the series (KD = 190 microM).
Epistemonikos ID: 9ae3ad8ce9b7ea4c344605cd09086d611455132f
First added on: Sep 15, 2024