Prospective, multicenter, randomized controlled, non inferiority clinical trials to evaluate the safety and efficacy of nanomembrane obturator for patent foramen ovale

INTERVENTION: Trial group:Implantation of nano membrane obturator for patent foramen ovale;Control group:Implantation of cardi‐o‐fix patent foramen ovale occluder; CONDITION: Patent foramen ovale PRIMARY OUTCOME: Successful rate of effective occlusion 12 months after operation; SECONDARY OUTCOME: Success rate of occluder implantation; INCLUSION CRITERIA: 1) The age of the patients was 18‐65 years old; 2) Be able to understand the purpose of the experiment, participate voluntarily and sign the informed consent form; 3) The presence of PFO was confirmed by tee or TTE; 4) Right heart contrast echocardiography (ctte) or transcranial Doppler foaming test (ctcd) confirmed the presence of moderate to large right to left shunt (calm state or after Valsalva maneuver or cough); 5) At least one of the following clinical conditions exists: a) Stroke of unknown origin complicated with PFO; e) Transient ischemic attack of unknown cause complicated with PFO; f) Recurrent migraine with PFO.