Comparison of the Relative Systemic Bioavailability of Topically Applied Diclofenac Diethylamine Administered with Phonophoresis and Soft Tissue Mobilization

INTERVENTION: Phonophoresis with Diclofenac Diethylamine contained in Relaxo gel Soft tissue mobilization with Diclofenac Diethylamine contained in Relaxo gel CONDITION: ; Pharmacokinetics / Relative Bioavailability Pharmacokinetics / Relative Bioavailability PRIMARY OUTCOME: Pharmacokinetic metrics: Paired‐samples t‐tests to evaluate differences in Cmax, Tmax and AUC30‐120 between the two treatment conditions. SECONDARY OUTCOME: Body Mass Index INCLUSION CRITERIA: Apparently healthy adult volunteers aged between 18–55 years. Participants able and willing to provide written informed consent and comply with study procedures. Participants not currently using any systemic or topical analgesics. Participants with intact skin at the site of application. Apparently healthy volunteers, not in any pain, distress, or with known disease