Nocturnal nutritional supplementation in advanced liver disease - a randomised trial

INTERVENTION: Single‐centre, stratified, randomised study to compare total body protein changes in patients with liver cirrhosis taking a nutritional supplement (2 cans Ensure Plus or equivalent) either at night‐time or daytime for 12 months. CONDITION: Liver cirrhosis PRIMARY OUTCOME: Total body protein change from baseline to 6 months. SECONDARY OUTCOME: Fatigue score GH/IGF axis Health‐related quality of life Physiologic function INCLUSION CRITERIA: Patients with chronic liver disease referred for nutritional support who have cirrhosis of the liver. Written informed consent.