Comparison of sitagliptin and glimepiride in patients with type 2 diabetes mellitus

INTERVENTION: sitagliptin glimepiride CONDITION: Type 2 diabetes mellitus PRIMARY OUTCOME: HbA1c, body weight, hypoglycemia SECONDARY OUTCOME: glycoalbumin, 1, 5‐anhydroglucitol, blood pressure, lipids, insulin, proinsulin, adiponectin, leptin, CRP, bone metabolic markers, durability, safety INCLUSION CRITERIA: Patients with type 2 diabetes inadequately controlled with following therapies (HbA1c 6.9 10.4%) 1) diet and exercise therapy 2) treated with glinides or biguanides or pioglitazone monotherapy 3) treated with glinides and biguanides or pioglitazone (dual therapy)