Rapid synthesis of a glycosylphosphatidylinositol-based malaria vaccine using automated solid-phase oligosaccharide synthesis.

Authors
Category Primary study
JournalJournal of the American Chemical Society
Year 2002
Described is an automated synthesis of hexasaccharide malarial toxin 1, currently under development as a malaria vaccine candidate. Using a combination of automated solid-phase methods and solution-phase fragment coupling, the target glycosylphosphatidylinositol was assembled in a matter of days, compared with several weeks for a comparable solution-phase synthesis.
Epistemonikos ID: 98091a0361f0667d85a9cafd1e25671d68495b39
First added on: Sep 15, 2024