A study comparing two skin treatments given by tiny needle pricks for treatment of facial dark patches.

INTERVENTION: Intervention1: Tranexamic acid: Tranexamic acid 10 percent solution is available as 5 ml ampoules containing 500 mg tranexamic acid. It will be applied as a thin layer on the face followed by microneedling with a 1 mm dermaroller until pinpoint bleeding occurs with at least ten passes in all four directions. 10 percent tranexamic acid solution will be applied again as a thin layer after the procedure. Such sessions will be carried out twice at a gap of 3 weeks. Intervention2: Platelet Rich Plasma: For preparing PRP, 10 mL of blood of patient will be withdrawn and placed in a tube containing anticoagulant sodium citrate. Double spin method will be used to prepare PRP. The first centrifugation will be slow at 1600 rpm for 10 minutes. The supernatant plasma will be withdrawn and recentrifuged. The second centrifugation will be done at a faster speed using 4000 rpm for 10 minutes. The platelet poor plasma will be decanted off and the platelet pellet will again be suspended in the remaining plasma to get platelet rich plasma. It will be applied as a thin layer on the face followed by microneedling with a 1 mm dermaroller until pinpoint bleeding occurs with at least ten passes in all four directions. PRP will be applied again as a thin layer after the procedure. Such sessions will be carried out twice at a gap of 3 weeks. Control Intervention1: NA: NA CONDITION: Health Condition 1: L811‐ Chloasma PRIMARY OUTCOME: reduction in modified melasma area and severity index score mMASITimepoint: week 0, 3, 7, 10, 14 SECONDARY OUTCOME: Melasma Quality of Life Scale MELASQOLTimepoint: week 0, 14 Patient satisfaction scoreTimepoint: week 0, 14 Physician assessment scaleTimepoint: week 0, 3, 7, 10, 14 INCLUSION CRITERIA: Patients with clinical diagnosis of melasma