Effects of intravenous and nebulized inhaled lidocaine on postoperative sore throat: a prospective randomized controlled trial

INTERVENTION: Normal saline group (S):Administer lidocaine 1.5 mg/kg intravenously and nebulize 10 mL of normal saline.;Lidocaine group (L):10 ml of normal saline was intravenously injected, and 1% lidocaine was inhaled by nebulization. The total dose was 2.0 mg per kilogram of body weight;Control group:Administer 10 ml of normal saline by intravenous injection and 10 ml of normal saline by nebulization inhalation.; CONDITION: Postoperative sore throat PRIMARY OUTCOME: The incidence of sore throat (POST) within 24 hours after surgery; SECONDARY OUTCOME: Record the changes of mean arterial pressure and heart rate of the patients before and after intubation;Record the incidence of coughing in patients from the moment tracheal intubation is removed after the operation to within 30 minutes;The VAS score for sore throat 24 hours after the operation and the incidence of nausea and vomiting; INCLUSION CRITERIA: 1.Age 18 years and older; 2.BMI18.5 30kg/m2; 3.American Society of Anesthesiologists ASA Classification: I ‐ II; 4.Elective surgery under general anesthesia with tracheal intubation should not exceed 2 hours; 5.Clinical data are complete, liver and kidney function is normal, and cardiovascular and cerebrovascular examinations show no abnormalities.