Predicting the Response to Montelukast by Genetic Variation in Asthmatics

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2003
The purpose of this study is to examine a specific variation in the genetic code for an enzyme (LTC4 synthase) which plays an important role in the airway inflammation associated with asthma. We hypothesize that asthmatic patients with this variant gene will have a better response to montelukast than patients with the wild type gene, as measured by the ability of montelukast to protect against a hypertonic saline challenge.
Epistemonikos ID: 9595dbd0480e5c7b840e1fccc678f158771e7958
First added on: May 04, 2024