Dynamic observation on changes of malondialdehyde,nitric oxide and superoxide dismutase in patients with severe acute respiratory syndrome and its significance

Objective: To dynamically observe the changes of malondialdehyde (MDA), nitric oxide(NO) and superoxide dismutase(SOD) in patients with severe acute respiratory syndrome(SARS) and to explore its significance. Methods: MDA, NO and SOD were determined by using bathyran chromatometry, nitrate reductase method, xanthine oxidase inhibition method in SARS patients during the first, recovery and followup stage, the front health doctors and nurses and health people. The significance of their changes were analyzed . Results: The mean of MDA during the first stage was higher than that of recovery stage and the mean of recovery stage was higher than that of followup stage and health people (all P 0.001).The mean of NO during the first stage was higher than that of other stages. The NO means of recovery and followup stage were secondly higher. The mean of SOD during the first stage was higher than that of recovery stage and was lower than that of health people( P =0.024), the mean of SOD during the recovery stage was lower than that of followup stage, the front health doctors and nurses and health people (all P 0.001). Conclusion: The pathological injury in pathogenesis of SARS is related to free radicals. SOD has the capacity of antiinjury.