A research of efficacy and safety of oxytocin treatment in children and adolescents with reactive attachment disorder using functional magnetic resonance imaging (fMRI)

INTERVENTION: Intranasal single administration of oxytocin Intranasal single administration of placebo CONDITION: Reactive Attachment Disorder PRIMARY OUTCOME: fMRI analysis : Comparison of brain activity change after oxytocin or placebo administration. SECONDARY OUTCOME: plasma oxytocin concentration ; oxytocin receptor gene polymorphism; neuropsychological test INCLUSION CRITERIA: 1) Patients with reactive attachment disorder based on the classifications in the diagnostic and statistical manual of mental disorders (DSM‐IV‐TR). Healthy children and adolescents with higher level of IQ 80. 2) Subjects within the age range of 8‐17 years old. 3) Must demonstrate an acceptable degree of compliance with medication and procedures in the opinion of the investigator.