Effects of Oral Xylitol on Subsequent Energy Intake

The subjects will participate in four study days. The screening will last 60 minutes, thestudy days about 4.5 hours each. After a simple‐carbohydrate standard dinner, thesubjects have to do an overnight fast until the next morning. Subjects will receive fixedequisweet doses of sucrose (33.5g), xylitol (33.5g), Ace‐K (0.1675g), or water as oralpre‐loads in a blinded, randomized (counterbalanced) fashion (t = ‐15 min). Fifteenminutes after the administration (t = 0 min), a standard solid test meal will bepresented and ad libitum energy intake will be measured. The end of the test meal will beafter 20 minutes or as soon as the subject stops eating for more than 5 minutes. Bloodsamples (to measure: glycemic control and GI hormones) will be collected at t = ‐16, t =‐1, t = 15, t = 30, t = 60, t = 90, t = 120, t = 150, t = 180 min and appetite‐relatedsensation rating will be collected at t = ‐16, t = ‐1, t = 15, t = 30, t = 60, t = 90, t= 120, t = 150, t = 180 min. GI symptoms and nausea are assessed at t = ‐16, ‐1, 30, 60,120 and 180 min. At t = ‐10 min subjects are asked to rate the perceived sweetness andliking of the pre‐load and at t = 180 min the perceived liking of the test meal.