Protective analgesia using bupivacaine and conventional release ibuprofen versus bupivacaine and sustained release ibuprofen for postoperative pain relief in patients undergoing third molar surgery: a randomised controlled trial.

INTERVENTION: Trade Name: Brufen Retard Pharmaceutical Form: Tablet Trade Name: Ibuprofen Pharmaceutical Form: Tablet Trade Name: Marcain 0.5% Pharmaceutical Form: Solution for injection CONDITION: Pain following surgical removal of impacted lower wisdom tooth/ teeth. PRIMARY OUTCOME: Main Objective: Improve postoperative pain experience for patients undergoing third molar surgery. Primary end point(s): Number of patients needing rescue medication within 6 hours following surgery. Secondary Objective: To test the concept of protective analgesia using combined effects of sustained release ibuprofen and bupivacaine nerve block in attenuation of postoperative pain following third molar surgery. INCLUSION CRITERIA: 1.Provision of written informed consent. 2.Male or female outpatients scheduled for surgical removal of one or more impacted mandibular third molar, where bone removal is judged to be needed and, if medically indicated, removal of the ipsilateral third molar in the upper jaw (indication for removal according to recently published NICE guideline). 3.Age 18 years and over. 4.BMI no more than 35 (kgm‐2). 5.Be able and to understand and comply with all study requirements. Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range