Efficacy Evaluation of Conservative Treatment with Flurbiprofen Gel Patch Combined with Moxibustion for Knee Osteoarthritis

INTERVENTION: Experimental group:Patients in the experimental group received topical flurbiprofen gel patch combined with moxibustion on the affected knee. Flurbiprofen gel patch, containing 40 mg of flurbiprofen per patch, was applied topically twice daily for two consecutive weeks. Heat‐sensitive moxibustion was adopted. Moxibustion‐sensitive points were detected around the knee joint in the region composed of Yinlingquan (SP9), Yanglingquan (GB34), Liangqiu (ST34) and Xuehai (SP10) acupoints. Moxibustion was performed for 15 minutes once daily, five times per week, for a total of two weeks.;Moxibustion alone control group:Heat‐sensitive moxibustion was adopted. Moxibustion‐sensitive points were detected around the knee joint in the region composed of Yinlingquan (SP9), Yanglingquan (GB34), Liangqiu (ST34) and Xuehai (SP10) acupoints. Moxibustion was performed for 15 minutes once daily, five times per week, for a total of two weeks.;Flurbiprofen patch alone control group:Patients in the experimental group received topical flurbiprofen gel patch combined with moxibustion on the affected knee. Flurbiprofen gel patch, containing 40 mg of flurbiprofen per patch, was applied topically twice daily for two consecutive weeks.; CONDITION: Knee Osteoarthritis PRIMARY OUTCOME: Symptom improvement rate; SECONDARY OUTCOME: the Western Ontarioand McMaster Universities Osteoarthritis Inde X(WOMAC) score;VAS score;IL‐1ß;TNF‐a; INCLUSION CRITERIA: 1. Meet the Western medical diagnostic criteria for osteoarthritis (Orthopedics, People's Medical Publishing House); 2. No gender restriction, aged 18–60 years; 3. No use of other therapeutic drugs (such as analgesics, hormones) or surgical treatment within the past 1 month; 4. Voluntarily participate in and comply with the treatment protocol, with signed informed consent; 5. No severe neurological, psychiatric or somatic diseases.