Comparison of analgesic and anti-inflammatory effect of topical application of ginger aqueous extract with local dexamethasone injection after extraction of mandibular wisdom teeth

Extracting the mandibular double-sided wisdom teeth.. In this double-blind clinical trial, anti-inflammatory and anti-inflammatory effects of topical administration of a 20% tissue bioadhesive made of 100% ginger extract and a mucosal dexamethasone injection of 1.6 mg after extraction of the wisdom teeth will be compared. The similarity of the mandibular teeth is performed by a qualified expert oral and maxillofacial radiologist through panoramic radiography images based on the indications in the radiology images and the classifications available in reference books as well as by a clinical examination by a oral and maxillofacial surgeon. The angle of tooth placement in the jaw, the amount of bone and soft tissue on the tooth, and the tooth position should be similar. Each patient will take amoxicillin 500 mg and metronidazole 400 mg 30 minutes before startingextraction. For each patient, the choice of which treatment is to be done on his right or left tooth will be done using random numbers. Patients will be injected with two carpool of lidocaine anesthetics with inferior alveolar nrve block technique, then removed by the surgeon and under the cut-off procedure of the mucoperiosteal envelope flap (in case of need for surgery) or by simple tooth extraction. Then, according to a randomized random number, in the cavity of the tooth extracted, the area of 4 cm 2 of the bioadhesive contains 20% ginger extract will be replaced or 1.8 ml of the dexamethasone dose of 1.6 mg will be injected. The degree of opening the patient's mouth (Trismus status) and the distance between the commisure of oral cavity of the patient and the tragus of his ear (checking the status of swelling) will be measured and recorded before surgery, 24 hours and 72 hours after surgery. A translated VAS pain intensity questionnaire will be provided for patients and they will determine the amount of pain in the respective hours (surgery day and one to three days after surgery). Also, in connection with taking medications, he will be allowed to use acetamin;Treatment - Drugs;In this double-blind clinical trial, anti-inflammatory and anti-inflammatory effects of topical administration of a 20% tissue bioadhesive made of 100% ginger extract and a mucosal dexamethasone injection of 1.6 mg after extraction of the wisdom teeth will be compared. The similarity of the mandibular teeth is performed by a qualified expert oral and maxillofacial radiologist through panoramic radiography images based on the indications in the radiology images and the classifications available in reference books as well as by a clinical examination by a oral and maxillofacial surgeon. The angle of tooth placement in the jaw, the amount of bone and soft tissue on the tooth, and the tooth position should be similar. Each patient will take amoxicillin 500 mg and metronidazole 400 mg 30 minutes before startingextraction. For each patient, the choice of which treatment is to be done on his right or left tooth will be done using random numbers. Patients will be injected with two carpool of l. The amount of pain. Timepoint: Day of intervention, one day after intervention, two days after intervention, three days after intervention. Method of measurement: VAS scale (number).;Mouth opening rate. Timepoint: Pre-intervention, 24 hours after intervention, 72 hours after intervention. Method of measurement: Millimeters.;Distance between the corner of the mouth and the tragus. Timepoint: Pre-intervention, 24 hours after intervention, 72 hours after intervention. Method of measurement: Millimeters.;The amount of acetaminophen codoine 300 mg taken. Timepoint: Day of intervention, one day after intervention, two days after intervention, three days after intervention. Method of measurement: questionnaire.. Age. Timepoint: Before intervention. Method of measurement: questionnaire.;Gender. Timepoint: Before intervention. Method of measurement: questionnaire.;Infection. Timepoint: Before intervention, 24 hours after intervention, 72 hours after intervention. Method of measurement: View, interview.;Any other anti-inflammatory or analgesic drug. Timepoint: three days after the intervention. Method of measurement: questionnaire..