Single-Dose versus Long-Term Antibiotic Prophylaxis for Breast Reconstruction with Tissue Expanders

INTERVENTION: Arm 1: Single Perioperative Antibiotic Dose. Patients received 1‐2 grams of cefazolin intravenously within 30 minutes prior to surgery, based on the participant’s weight (1 gram for less than 100 kg & 2 grams for greater than 100 kg). Arm 2: Prolonged Antibiotic Dose. Patients also received 1‐2 grams of cefazolin intravenously within 30 minutes prior to surgery, based on the participant’s weight (1 gram for less than 100 kg & 2 grams for greater than 100 kg). After surgery patients received an additional 24 hours of intravenous dosing of cefazolin and then seven days of cephalexin 500 mg by mouth 3‐4 times per day as directed. CONDITION: Surgical Site Infection PRIMARY OUTCOME: Primary Outcome 1: Superficial Surgical Site Infection as defined by the Centers for Disease Control (CDC) SECONDARY OUTCOME: Nil INCLUSION CRITERIA: 1. Age greater than or equal to 18 2. Female 3. Patients undergoing mastectomy with immediate breast reconstruction with tissue expanders 4. Patients who sign informed consent 5. Patients who do not meet any of the exclusion criteria