Randomised clinical trial: low-volume bowel preparation for colonoscopy - a comparison between two different PEG-based formulations

Background Low-volume bowel preparations with polyethylene glycol (PEG) have been shown to provide an equivalent cleansing with improved tolerability as compared with standard PEG bowel preparation for colonoscopy. A new iso-osmotic sulphate-free formulation of PEG-Citrate-Simethicone (PEG-CS) in combination with bisacodyl has been recently developed. Aim To compare the quality of bowel cleansing with PEG-CS with bisacodyl vs. PEG-Ascorbate (PEG-ASC) in adult out-patients undergoing colonoscopy. Methods Randomised, observer-blind, parallel group study in adult out-patients undergoing colonoscopy in five Italian centres. Both preparations were taken the evening before the procedure. Subjects were instructed to take 24 tablets of 5 similar to mg bisacodyl at 16:00 similar to hours and 2 similar to L of PEG-CS at 20:00 similar to hours or 2 similar to L of PEG-ASC plus 1 similar to L of additional water the day before colonoscopy. Bowel cleansing was evaluated according to the Boston Bowel Preparation Scale (=6 scores were considered as clinical success), and mucosal visibility according to a 3-point scale. Tolerability, acceptability and compliance were also evaluated. Results Four hundred and eight patients were randomly allocated to PEG-CS and bisacodyl (n similar to=similar to 204, male patient 48%, mean age 59.1 similar to years) or PEG-ASC (n similar to=similar to 204, male patient 51%, age 59.4 similar to years). In the planned per-protocol analysis, the rate of successful preparation was 79.1% following PEG-CS with bisacodyl, and 70% following PEG-ASC (P similar to

Epistemonikos ID: 936b970c271b954825acb2dc21becd18d2b7a78f
First added on: May 08, 2022