Evaluation of adding clonidine to local anesthetic in regional anesthesia for upper extremity surgery

INTERVENTION: Control group: administration of 25 ml bupivacaine 0.5% for supraclavicular blockade Intervention 1: Intervention group: adding clonidine 75 mcg to bupivacaine 0.5% in supraclavicular blockade. Intervention 2: Control group: administration of 25 ml bupivacaine 0.5% for supraclavicular blockade. Intervention group: adding clonidine 75 mcg to bupivacaine 0.5% in supraclavicular blockade Treatment ‐ Drugs CONDITION: Condition 1: Fracture of upper limb. Condition 2: Local anaesthetics. ; Fracture of upper limb ; Local anaesthetics Fracture of upper limb Local anaesthetics PRIMARY OUTCOME: Sensory and motor blockade in upper extremity. Timepoint: from start of injection to one hour after surgry. Method of measurement: physical exam of sensation and movement in the upper limb. SECONDARY OUTCOME: Complications. Timepoint: from start of injection to one hour after surgry. Method of measurement: patient evaluation and observation. INCLUSION CRITERIA: INCLUSION CRITERIA: patients aged 20–60 years (ASA physical status I or II) of both sex, who were candidate for upper extremity (hand, forearm, elbow or arm) surgery, referred to Rasool‐Akram hospital. Exclusion criteria: severe uncontrolled underlying diseases (coagulopathy, seizure, cardiac, ...), history of cigarette, opioid, or alcohol abuser, allergy to local anesthetic or clonidine , patient refusal