Music Therapy in Sickle Cell Disease Vaso-occlusive Crisis

Sickle cell disease, the most frequent monogenic disease in France and in the world, is induced by a mutation in the β‐globin chain of hemoglobin with production of hemoglobin S. The course of the disease is characterized by very painful, for which treatment is notoriously limited. vaso‐occlusive crises pain is multifactorial with biological and psychological components. A few studies suggest a beneficial effect of relaxation techniques in the management of Sickle cell disease pain. MUSIC CARE® is a novative music therapy program which proved efficient in different models of acute or chronic pain. the hypothesis is that this program can help alleviate severe pain in synergy with traditional treatment in SS Sickle cell disease patients, via a dual biological and psychological effect. The main objective of this prospective, randomized, open label study is to test the effect of the music therapy program MUSIC CARE® on daily mean morphine consumption during the 3 first days of hospitalisation for severe vaso‐occlusive crises in adult SS Sickle cell disease patients. Secondary outcomes will include mean daily Visual Analogic Scale during the first 3 days of hospitalization for severe vaso‐occlusive crises, acute complications of vaso‐occlusive crises, duration of severe vaso‐occlusive crises and of hospitalization, Hospital Anxiety and Depression Scale. 20 patients will be included in each group for this pilot study.