Fat Filtration and Organ Injury following Cardiac Surgery

INTERVENTION: Use of the RemoweLL Oxygenator containing a lipid and leucocyte depleting filter against current standard oxygenator during cardiopulmonary bypass for patients undergoing coronary artery bypass grafting. CONDITION: Cardiopulmonary bypass ; Surgery PRIMARY OUTCOME: 1. Concentration of lipid microemboli measured using light microscopy and Oil Red O staining before and after cardiopulmonary bypass compared to control; 2. Percentage of activated leucocytes using flow cytometry marker CD11b before and after cardiopulmonary bypass compared to control SECONDARY OUTCOME: Levels of biochemical markers of organ injury, specifically ; 1. Brain (neuron‐specific enolase [NSE]); 2. Kidneys (Cystatin C and standard laboratory tests) and ; 3. Pulmonary function as measured by calculation of the respiratory index; Comparison between before and after results with trial and standard oxygenator. INCLUSION CRITERIA: 1. Participant is willing and able to give informed consent for participation in the study ‐ any documented history of cognitive impairment will exclude the patient as this may have an effect on biochemical markers of cerebral injury 2. Male or female, aged 18 years or above 3. Patients undergoing elective Coronary Artery Bypass Graft (CABG) surgery 4. Angiographically proven coronary artery stenosis