Self-Management of Altered environmental Reactivity Training SCANning

Authors
Category Primary study
Registry of TrialsNetherlands Trial Register
Year 2013
INTERVENTION: 1. Psychosis & Depression Trial: The verum condition consists of a 4 session ACT‐training, during 6 weeks of ESM assessments with signals at random time‐points to fill out questionnaires, followed by detachment and acceptance exercises, as person‐tailored and interactive feedback based on their ESM. The control condition consists of 4 sessions with a group discussion on actualities; 2. Anxiety Trial: Exposure therapy in the clinical condition of phobia. The control condition consists of relaxation training. CONDITION: ; Young adults, Psychopathology ; ; PRIMARY OUTCOME: Neuroimaging effects:; ; The primary outcome measure in the intervention study is the pre/post intervention change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward.; ; The primary outcome measure in the observational study is the pre/post follow‐up period change of fMRI BOLD signal in the regions of interest involved in aversive learning, in reward learning and in anticipation of reward. SECONDARY OUTCOME: Secondary outcomes: ; ; 1. Reward experience; ; ; 2. Stress reactivity and salience reactivity as measured with ESM; ; ; 3. Cross‐sectional associations between fMRI and ESM and psychopathology. ; ; ; ; Ancillary outcomes: ; ; Changes in depression, psychosis and fear psychopathology scores. INCLUSION CRITERIA: Two samples of adolescents / young adults aged 16‐25 years with sub‐diagnostic, subclinical stage 1b levels of depression and or psychosis (MADRS=10 and/or CAPE=12, and GAF<70, following the guidelines of McGorry et al [1] corresponding with approximately 15% of the general population) (n=132), fear (n=66), as well as a comparison group with no/low level of psychopathology (n=50) based on the rating‐scores of psychopathology using questionnaires will be studied.
Epistemonikos ID: 91c84a21e00fca3b2b2df40489d5d08ef8c0416f
First added on: Aug 22, 2024