Effect of Propranolol In patients with Cavernous malformations of the central nervous system: a randomised controlled trial

INTERVENTION: Experimental group:Oral propranolol for 4 to 8 weeks before surgery;Control group:Without invention before surgery; CONDITION: Cavernous malformations of the central nervous system PRIMARY OUTCOME: Lesion Size on MRI;Neurological outcome; SECONDARY OUTCOME: Biomarkers of the blood and tissue samples; INCLUSION CRITERIA: 1. Patients with symptomatic cavernous malformations of the central nervous system requiring surgical treatment; 2. Written informed consent to participate in the study prior to any study procedures; 3. Negative pregnancy test at time of enrollment for women of child‐bearing potential; 4. Heart rate greater than 50 beats per minute; 5. Systolic blood pressure > 90 mmHg.