The effects of a cognition enhancer (CILTEP) on a cognitive test battery and EEG in middle-aged and old volunteers

INTERVENTION: Volunteers will be tested on 2 separate days and will be administered either CILTEP or a placebo. Before inclusion, they will undergo a memory and a medical screening The order of treatment will be randomized. CONDITION: Long term results ; ; PRIMARY OUTCOME: To establish the effects of CILTEP on cognition, especially memory. The main cognitive tests that will be used are the verbal learning task (VLT), in which participants need to memorize words that are presented on a screen, and the spatial pattern separation test, using photographs to assess episodic memory. SECONDARY OUTCOME: Performance in several other cognitive tests will be our secondary objective. We will examine the effects of CILTEP on working memory performance using an n‐back task, on information processing speed using the digit symbol substitution test (DSST), on motor speed using a simple and choice reaction time task (SRT and CRT, respectively), on attention and concept shifting using the trail making test, and on response inhibition and focused attention using the Stroop. A sensory gating paradigm is included to examine the effect of our treatment on specific ERP components related to basic auditory processing. ; INCLUSION CRITERIA: 1. Male or female; 2. 30 to 40 or 60 to 75 years of age; 3. healthy (i.e. absence of all exclusion criteria); 4. body mass index between 18.5 and 30; 5. Verbal Learning Test screening score within the ‐1 and +1 standard deviation; 6. willingness to sign an informed consent.