The Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation in Individuals With Tiletamine Use Disorder

Tiletamine use disorder has emerged as a significant public health concern characterizedby persistent psychological craving and high relapse rates. This randomized,double‐blind, sham‐controlled clinical trial aims to evaluate whether transcutaneousauricular vagus nerve stimulation (taVNS) can reduce craving levels and improve otheroutcomes in individuals with tiletamine dependence. Multimodal assessments includingelectroencephalography (EEG), electrocardiography (ECG) , behavioral paradigms measuresand clinical scales will be conducted before and after the treatment.This study seeks to establish a non‐invasive vagus nerve stimulation strategy forsubstance use disorders and explore the treatment mechanism.