Mindful Breathing and tDCS for Depression

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2019
Aim 1: To demonstrate the feasibility of recruiting and randomizing adolescents with depression to a research protocol involving MBT and tDCS. The investigators expect that adolescents will be willing to enroll in a randomized trial involving MBT and tDCS. Aim 2: To test the tolerability of MBT and tDCS in adolescents. The investigators expect that MBT will be well‐tolerated and that active tDCS will show no difference in tolerance compared to sham stimulation. Aim 3: To examine whether tDCS can enhance the effects of MBT. The investigators expect the MBT + tDCS group will show greater reduction in depressive symptoms compared to the MBT + sham stimulation group. Aim 4: To examine the mechanisms of MBT +/‐ tDCS treatment. The investigators expect that depression symptom improvement will be associated with decreased rumination, improvements in emotion regulation, increased task‐based and resting state DLPFC‐DMN and DLPFC‐amygdala connectivity, as well as increased DLPFC activation and reduced amygdala activation during rumination and emotion processing tasks. The investigators also expect reduced alpha asymmetry and reduced LPP amplitude during emotion regulation and emotion processing. The investigators expect these changes will be greatest in the active tDCS + MBT group.
Epistemonikos ID: 9033a5b28f35cecb27139099fc6966ecb7265a52
First added on: May 22, 2024